Perspective on Translating Biomaterials Into Glioma Therapy: Lessons From in vitro Models.

摘要: Glioblastoma (GBM) is the most common and malignant form of brain cancer. Even with aggressive standard care, GBM almost always recurs because its diffuse, infiltrative nature makes these tumors difficult to treat. The use biomaterials one strategy that has been, being, employed study overcome recurrence. Biomaterials have been used in two ways: vitro as mediums which model tumor microenvironment, vivo sustain release cytotoxic therapeutics. In systems are a useful platform for studying effects drugs tissue-level effectors on cells physiologically relevant context. These aided examination how glioma respond variety natural, synthetic, semi-synthetic varying substrate properties, biochemical factor presentations, non-malignant parenchymal cell compositions both 2D 3D environments. current paradigm completely different, however. Polymeric implants simply line post-surgical resection cavities deliver secondary therapies, offering moderate impacts survival. Instead, perhaps we can data generated from design novel biomaterial-based treatments akin tissue engineering approach. Here offer our perspective topic, summarizing identify facets biology discussing elements show promise translating new therapies GBM.