Endothelium is required for 12-hydroperoxyeicosatetraenoic acid-induced vasoconstriction
作者： Makoto Nishiyama , Hisayo Okamoto , Takashi Watanabe , Tomokatsu Hori , Tomio Sasaki
DOI: 10.1016/S0014-2999(97)01353-8
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摘要: The pharmacological effects of 12-hydroperoxyeicosatetraenoic acid (12-HPETE) were examined using isolated canine basilar artery segments and isometric tension recording. 12-HPETE produced transient contraction the segment while arachidonic or 12-hydroxyeicosatetraenoic (12-HETE) had a much lower potency. 12-HPETE-induced which showed requirement functional endothelium rapid insensitivity to re-administered 12-HPETE, was completely inhibited by potassium channel blocker, glibenclamide. Other hydroperoxides did cross-desensitize contraction, however, 12-HETE not affect markedly. Here, we present that is involved in regulation vascular via its on endothelium.
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