Hepatocyte growth factor in blood and gastric cancer risk: A nested case-control study
作者： Jieun Jang , Seung Hyun Ma , Kwang-Pil Ko , Bo Yul Choi , Keun-Young Yoo
DOI: 10.1158/1055-9965.EPI-19-0436
关键词:
摘要: Background: Potential of hepatocyte growth factor (HGF)–stimulating signaling pathways related to cytotoxin-associated gene A (CagA) predict gastric cancer development has not been fully investigated. Methods: We conducted a nested case–control study consisting 238 cases and matched controls within the Korean Multicenter Cancer Cohort. Plasma HGF concentrations were measured with human ELISA. Odds ratios (OR) 95% confidence intervals (CI) for according level calculated using conditional logistic regression model. Results: Sequential elevation risk increase was observed (OR, 10.99; CI, 4.91–24.62) highest quartile (≥364 pg/mL) versus lowest ( Conclusions: Our results suggest as potential biomarker development. Impact: These findings useful risk. Further research assess based on biomarkers, including HGF, may contribute primary prevention cancer.
aacrjournals.org
sci-hub.se 参考文章(31)
Soung Hoon Chang, Sue Kyung Park, Keun Young Yoo, Daehee Kang, Hai Rim Shin, Kun Sei Lee, Duck Hee Lee, Korean Multi-center Cancer Cohort Study including a Biological Materials Bank (KMCC-I). Asian Pacific Journal of Cancer Prevention. ,vol. 3, pp. 85- 92 ,(2002)
Xin Yong, Bo Tang, Bo-Sheng Li, Rui Xie, Chang-Jiang Hu, Gang Luo, Yong Qin, Hui Dong, Shi-Ming Yang, Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways Cell Communication and Signaling. ,vol. 13, pp. 30- 30 ,(2015) , 10.1186/S12964-015-0111-0
L. Monteiro, B. Bergey, N. Gras, F. Mégraud, Evaluation of the performance of the Helico Blot 2.1 as a tool to investigate the virulence properties of Helicobacter pylori Clinical Microbiology and Infection. ,vol. 8, pp. 676- 679 ,(2002) , 10.1046/J.1469-0691.2002.00438.X
Jae Jeong Yang, Lisa Y Cho, Seung Hyun Ma, Kwang-Pil Ko, Aesun Shin, Bo Youl Choi, Dong Soo Han, Kyu Sang Song, Yong Sung Kim, Soung-Hoon Chang, Hai-Rim Shin, Daehee Kang, Keun-Young Yoo, Sue K Park, None, Oncogenic CagA Promotes Gastric Cancer Risk via Activating ERK Signaling Pathways: A Nested Case-Control Study PLoS ONE. ,vol. 6, pp. e21155- ,(2011) , 10.1371/JOURNAL.PONE.0021155
Yuri Churin, Laila Al-Ghoul, Oliver Kepp, Thomas F. Meyer, Walter Birchmeier, Michael Naumann, Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response Journal of Cell Biology. ,vol. 161, pp. 249- 255 ,(2003) , 10.1083/JCB.200208039
Y Yasunaga, Y Shinomura, S Kanayama, Y Higashimoto, M Yabu, Y Miyazaki, S Kondo, Y Murayama, H Nishibayashi, S Kitamura, Y Matsuzawa, Increased production of interleukin 1 beta and hepatocyte growth factor may contribute to foveolar hyperplasia in enlarged fold gastritis. Gut. ,vol. 39, pp. 787- 794 ,(1996) , 10.1136/GUT.39.6.787
K. Tanaka, C. Miki, R. Wakuda, M. Kobayashi, H. Tonouchi, M. Kusunoki, Circulating level of hepatocyte growth factor as a useful tumor marker in patients with early-stage gastric carcinoma. Scandinavian Journal of Gastroenterology. ,vol. 39, pp. 754- 760 ,(2004) , 10.1080/00365520410005973
Steffen Backert, Elke Ziska, Volker Brinkmann, Ursula Zimny-Arndt, Alan Fauconnier, Peter R. Jungblut, Michael Naumann, Thomas F. Meyer, Translocation of the Helicobacter pylori CagA protein in gastric epithelial cells by a type IV secretion apparatus. Cellular Microbiology. ,vol. 2, pp. 155- 164 ,(2000) , 10.1046/J.1462-5822.2000.00043.X
Jae Jeong Yang, Lisa Y. Cho, Kwang-Pil Ko, Aesun Shin, Seung Hyun Ma, Bo Youl Choi, Dong Soo Han, Kyu Sang Song, Yong Sung Kim, Jong-Young Lee, Bok Ghee Han, Soung-Hoon Chang, Hai-Rim Shin, Daehee Kang, Keun-Young Yoo, Sue K. Park, Genetic Susceptibility on CagA-Interacting Molecules and Gene-Environment Interaction with Phytoestrogens: A Putative Risk Factor for Gastric Cancer PLoS ONE. ,vol. 7, pp. e31020- ,(2012) , 10.1371/JOURNAL.PONE.0031020
Sufi HZ Rahman, M Golam Azam, M Anisur Rahman, MS Arfi n, M Mahbub Alam, Tareq M Bhuiyan, Nasim Ahmed, Motiur Rahman, Shamsun Nahar, MS Hassan, Non-invasive diagnosis of H pylori infection: evaluation of serological tests with and without current infection marker CIM. World Journal of Gastroenterology. ,vol. 14, pp. 1231- 1236 ,(2008) , 10.3748/WJG.14.1231