Tumor Bioelectric Potential and its Possible Exploitation for Tumor Growth Retardation

摘要: The objective was to observe the effect of externally applied direct current on a murine tumor model (fibrosarcoma Sa-1 syngeneic A/J mice) and test hypothesis involving changing tumor's inherent negative bioelectric potential by that means. Direct 0.6 mA, 15 min/day, 9 consecutive days, started after tumors reached 50 ± 30 mm4 delivered through stainless-steel needle electrodes with cathode inserted into anode subcutaneously placed in its vicinity, Electrotherapy produced significant retardation growth. Tumor bioelectrical respect surrounding tissue measured prior immediately therapy. short-term imposition (voltage difference imposed therapy) depended therapy electrotherapy group: Pearson's correlation coefficient 0.035 control 0.569 group. Long-term bioel...