An experimental study on the early diagnosis of traumatic brain injury in rabbits based on a noncontact and portable system.

摘要: Closed cerebral hemorrhage (CCH) is a common symptom in traumatic brain injury (TBI) patients who suffer intracranial with the dura mater remaining intact. The diagnosis of CCH prior to hospitalization and early stage disease can help get earlier treatments that improve outcomes. In this study, noncontact, portable system for TBI-induced detection was constructed measures magnetic induction phase shift (MIPS), which associated mean conductivity caused by ratio between liquid (blood/CSF tissues) change. To evaluate performance system, rabbit model two severity levels established based on horizontal biological impactor BIM-II, whose feasibility verified computed tomography images three sections serial slices. There were groups involved experiments (group 1 10 TBI rabbits simulated hammer hit air pressure 600 kPa BIM-II group 2 650 kPa). MIPS values obtained within 30 min before after injury. 1, showed constant downward trend minimum value -11.17 ± 2.91° at 30th impact BIM-II. After impact, until 25th min, -16.81 2.10°. Unlike an upward point. Before injury, both did not obviously change measurement. Using support vector machine same time point classification accuracy types shown be beyond 90%. Combined pathological mechanisms, only achieve functional changes but also distinguish different severities CCH.