Predictive Modeling of Signaling Transduction Mediated by Tyrosine-Kinase Receptors

摘要: HER members of the tyrosine-kinase family transmembrane receptors are initiators signaling cascades driving crucial cellular process, such as gene transcription, cell cycle progression, apoptosis. Given their capacity oncogenic transformation these target selective anticancer drugs, which in-vivo however not effective anticipated by in-vitro experiments. Translating inhibitors into therapies to block will be facilitated models that can provide reliable predictions for evolution intricate mediated networks. This work presents a process-algebra based approach compactly specify and simulate models. The proposed activation model easily reused building in larger signaling.