Drug research: myths, hype and reality.

摘要: Lack of success with early combinatorial chemistry and high-throughput screening approaches resulted from inappropriate compound selection. We are now aware that compounds should be either 'lead-like' or 'drug-like' have the potential to orally available. However, there is a growing tendency misuse such terms overestimate their importance, overemphasize ADME problems in clinical failure. Sometimes, this goes hand-in-hand an uncritical application silico methods. Structure-based computer-aided can only as good medicinal they based on. The search for new drugs, especially lead optimization, evolutionary process likely successful if methods merge classical knowledge.