Anemia and Mortality in Heart Failure Patients: A Systematic Review and Meta-Analysis

摘要: Objectives The aim of this study was to assess the effect anemia on mortality in chronic heart failure (CHF). Background Anemia is frequently observed patients with CHF, and evidence suggests that might be associated an increased mortality. Methods A systematic literature search MEDLINE (through November 2007) for English language articles performed. In addition, a manual We included cohort studies retrospective secondary analyses randomized controlled trials whose primary objective analyze association between CHF. Of total 1,327 initial studies, we 34 comprising 153,180 patients. Information design, patient characteristics, outcome, potential confounders were extracted. Results defined by criteria used original articles. CHF patients, 37.2% anemic. After minimal follow-up 6 months, 46.8% anemic died compared 29.5% nonanemic Crude risk odds ratio 1.96 (95% confidence interval: 1.74 2.21, p Conclusions both systolic diastolic should, therefore, considered as useful prognosticator, therapeutic strategies aimed increase hemoglobin levels should investigated.