Prions Causing Transmissible Neurodegenerative Diseases

摘要: Seven diseases, four of animals and three humans, are probably caused by prions (Table 12.1). The unusual properties the infectious pathogens causing scrapie prompted introduction term “prion” to distinguish this class particles from viruses viroids.1 slow agents that cause transmissible mink encephalopathy (TME), chronic wasting disease (CWD), kuru not well characterized; thus, further knowledge about these must be obtained before they can firmly classified as prions. Much more is known prion Creutzfeldt-Jakob (CJD), Gerstmann-Straussler-Scheinker syndrome (GSS), bovine spongiform (BSE).2–4 For ease discussion, all diseases listed in Table 12.1 referred even though a etiology considered tentative until molecular each agent defined.5