Synaptophysin and GAP-43 mRNA levels in the hippocampus of subjects with schizophrenia.
作者： Maree J. Webster , Cynthia Shannon Weickert , Mary M. Herman , Thomas M. Hyde , Joel E. Kleinman
DOI: 10.1016/S0920-9964(00)00052-9
关键词:
摘要: Synaptophysin and growth associated protein-43 (GAP-43) are synaptic proteins colocalized to the presynaptic terminal, involved in regulating transmitter release plasticity. Recent studies have proposed an alteration number of synapses brains individuals with schizophrenia. As a corollary, we hypothesized that there may be level mRNAs code for patients Using situ hybridization, investigated levels synaptophysin GAP-43 mRNA medial temporal lobe 10 normal subjects, 11 subjects schizophrenia psychiatric control subjects. were significantly reduced several hippocampal subfields both schizophrenic groups. not either group. The implications these findings discussed relation neuroleptic treatment pathophysiology mental illness.
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