Urokinase-type plasminogen activator (uPA) and its receptor (CD87): a new target in tumor invasion and metastasis.

摘要: Extravasation and intravasation of tumor cells in solid malignant tumors is controlled by 3 steps: 1) attachment to interaction with components the basement membrane extracellular matrix, 2) local proteolysis, 3) cell migration. Evidence has accumulated that different types tumor-associated proteases, their inhibitors receptors are involved invasion metastasis. Four classes proteases known be correlated phenotype: Matrix metalloproteases; including collagenases, gelatinases stromelysins. Cysteine proteases; cathepsins B L. Aspartyl protease cathepsin D. 4) Serine plasmin tissue-type plasminogen activator (tPA) urokinase-type (uPA). A strong independent prognostic value (relapse-free and/or overall survival) especially been demonstrated for uPA its inhibitor PAI-1 patients cancer breast, ovary, stomach, esophagus, colon, lung, kidney thus predicting course disease. The correlation between elevated values primary tissues phenotype prompted explore new biology-oriented concepts order suppress or receptor (CD87) expression abrogate CD87. Various very approaches interfere reactivity CD87 at gene protein level were successfully tested antisense oligonucleotides, antibodies, recombinant synthetic analogues.