Short-term aromatase inhibition induces prostatic alterations in adult wistar rat: A biochemical, histopathological and immunohistochemical study

摘要: Abstract Purpose This study aimed to evaluate the effects of estrogen reduction on amyloid deposition, some lipid metabolism and oxidative stress markers, PSA-like production p63 expression in prostate adult rat. Methods Aromatase inhibitor: Formestane (4-OHA), was administrated male rats, at a dose 0.1 mg/kg b.w./day, for 10 days. The control group (CONT) received same volume placebo injection (NaCl 0.9%). Results 4-OHA treatment induced significant accumulation intraprostatic cholesterol (138.90 ± 17.64 vs 85.12 ± 2.87, p = 0.01); against an insignificant diminution malondialdehyde (412.6 ± 54.35 842.70 ± 336.50, p > 0.05) glutathione (2.40 ± 0.23 3.65 ± 0.88, p > 0.05). associated with decrease nitric oxide (31.76 ± 7.07 179.40 ± 58.35, p = 0.024). Additionally, significantly increased (11.12 ± 2.78 3.91 ± 0.43, p = 0.043). prostatic histology revealed all lobes smooth muscle layer growth (p  Discussion conclusion inhibition, rat, alters function by reducing availability inducing deposition along limiting differentiation basal cells, through lobe-specific p63-overexpression.