Abnormal monocyte chemotaxis in patients with chronic purulent rhinosinusitis: an effect of retroviral p15E-related factors in serum.

摘要: Earlier we reported that about 60% of patients suffering from unexplained relapsing chronic purulent rhinosinusitis show a defective T cell-mediated immunity to commensal microorganisms the upper respiratory tract. The monocyte chemotactic responsiveness was assessed in 40 these by means polarization assay. Impaired FMLP-induced found 26 tested. could be explained p15E-related factor detectable serum patients: addition fractions less than 25 kD healthy donor monocytes resulted an inhibition polarization; monoclonal antibody directed against p15E neutralized this inhibitory effect. In individual patients, decreased correlated well with presence serum, as cell reactivity.