Differential effects on glial activation by a direct versus an indirect thrombin inhibitor.

摘要: Abstract Thrombin is a potent regulator of brain function in health and disease, modulating glial activation inflammation. inhibitors, several which are clinical use as anti-coagulants, can reduce thrombin-dependent neuroinflammation pathological conditions. However, their effects healthy CNS largely unknown. In adult mice, we compared the treatment by direct thrombin inhibitor dabigatran etexilate (DE), to those warfarin, acts preventing vitamin K recycling essential for coagulation. After 4 weeks, warfarin increased both astrocyte GFAP microglia Iba-1 staining throughout CNS; whereas DE reduced expression markers. Warfarin, but not DE, sulfatide levels; showed longer lasting changes cerebellar gene expression. also mouse model Alzheimer's although no amyloid plaque burden were observed. These results suggest that with inhibitors may be preferable agents levels have potential increase activation.