Regioselective synthesis of 7,8-dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives: A new drug-like heterocyclic scaffold.
作者： Nikolay T Tzvetkov , Harald Euler , Christa E Müller
DOI: 10.3762/BJOC.8.181
关键词:
摘要: Dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives were prepared by successive N3- and N1-alkylation of hydantoins, followed regioselective thionation subsequent cyclization under mild conditions. In a final alkylation step further substituent may be introduced. The synthetic strategy allows broad structural variation this new drug-like heterobicyclic scaffold. addition to extensive NMR MS analyses, the structure one derivative was confirmed X-ray crystallography.
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