Positron emission tomographic studies of aging and Alzheimer disease.
作者： C Gentes , Y Yonekura , B Reisberg , M J de Leon , A P Wolf
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摘要: In this study the positron emission tomographic (PET)-18F-2-deoxy-2-fluoro-D-glucose (FDG) technique was used to both normal aging and senile dementia. The results derived from 15 young subjects (mean age, 26 +/- 5 years) 22 elderly 66 7 failed indicate significant metabolic changes associated with age. A group of 24 patients dementia 73 showed consistent diminutions in regional glucose use relative normals. Across all brain regions were 17%-24%. There also correlations between measures cognitive functioning. Discriminant function classification analysis that better than 80% accuracy can be achieved for individual PET measures. These data suggest a possible future diagnostic
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