Human tuberculosis predates domestication in ancient Syria

摘要: The question of pre-neolithic tuberculosis is still open in paleopathological perspective. One the major interests to explore what type infection could have existed around early stage animal domestication. Paleopathological lesions evoking skeletal TB were observed on five human skeletons coming from two PPNB sites Syria, which belongs geographical cradle agriculture. These represent respectively pre-domestication phase (Dja'de el Mughara, Northern 8800-8300 BCE cal.) and domestication (Tell Aswad, Southern 8200-7600 cal.). MicroCT scan analyses performed specimens (one per site) revealed microscopic changes favor infection. Detection lipid biomarkers positive for site). Initial molecular analysis further indicates presence one individual Dja'de. Interestingly, no morphological evidence was remains wild newly domesticated species, discovered these sites. observations strongly suggest before at its stages.