Fibroblast activation in vascular inflammation

摘要: Summary.  Vascular inflammation is implicated in both local and systemic inflammatory conditions. Endothelial activation leukocyte extravasation are key events vascular inflammation. Lately, the role of stromal microenvironment as a source proinflammatory stimuli has become increasingly appreciated. Stromal fibroblasts produce cytokines, growth factors proteases that trigger maintain acute chronic Fibroblasts have been associated with connective tissue pathologies such scar formation fibrosis, but recent research also connected them dysfunctions. able to modulate endothelial cell functions paracrine manner, including promotion angiogenesis. They activate attract leukocytes. can thus cause switch cells, promote infiltration into tissues. New insights adventitial further strengthened link between functions. This review focuses on inducing maintaining inflammation, describes findings concepts field, along examples pathologic implications.