Contribution of white matter hyperintensities, medial temporal lobe atrophy and cortical atrophy on outcome, seven to twelve years after ECT in severely depressed geriatric patients

摘要: Background: Depression and cognitive decline are highly prevalent often coexisting, however, the association between depression dementia remains unclear. White matter hyperintensities (WMH), medial temporal lobe atrophy (MTA) global cortical (GCA) associated with depression, mild impairment dementia; these structural abnormalities may therefore represent a common underlying mechanism of diseases. We conducted naturalistic prospective follow-up study in patients severe geriatric who were formerly treated ECT. The aim was to investigate effects brain on decline, survival. Method: Survival data 76 obtained. 39 (51.3%) them also participated study. Cognitive identified 7–12 years after ECT (median 8.0), using Informant Questionnaire Decline Elderly (IQCODE). A diagnosis obtained from family doctor patients. Results: Forty-two out (55.3%) died during follow-up. Twenty-four remained (65.1%) reported 7 among (17.9%) diagnosed dementia. psychotic symptoms significantly absence at (p¼0.007). WMH mortality (p log rank¼0.048). Finally, we observed trend significance GCA (p¼0.078), Conclusions: is subtype that might not be Moderate or before our cohort depressed higher possibly