Clinicopathologic and Prognostic Value of Serum Carbohydrate Antigen 19-9 in Gastric Cancer: A Meta-Analysis.
作者： Yong-xi Song , Xuan-zhang Huang , Peng Gao , Jing-xu Sun , Xiao-wan Chen
DOI: 10.1155/2015/549843
关键词:
摘要: Background. The clinical value of carbohydrate antigen (CA) 19-9 in gastric cancer is controversial. We evaluated the clinicopathologic and prognostic CA cancer. Methods. A literature search was conducted PubMed Embase databases. Odds ratios (ORs), risk (RR), hazard (HRs), 95% confidence intervals (CIs) were used as effect measures. Results. Thirty-eight studies included. Results showed that there significant differences incidence high levels between stages III/IV I/II groups (OR = 3.36; CI 2.34–4.84), pT3/T4 pT1/T2 2.40; 1.60–3.59), lymph node-positive node-negative 2.91; 2.21–3.84), metastasis-positive metastasis-negative 2.76; 1.12–6.82), vessel invasion-positive invasion-negative 1.66; 1.11–2.48). Moreover, significantly associated with poor overall survival (HR 1.83; 1.56–2.15), disease-free 1.85; 1.16–2.95), disease-specific 1.33; 1.10–1.60) Conclusions. Our meta-analysis indicates characteristics a prognosis.
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Uesaka K, Kodera Y, Yasui K, Torii A, Kito T, Yamamura Y, Hirai T, Morimoto T, Kato T, The prognostic value of preoperative serum levels of CEA and CA19-9 in patients with gastric cancer The American Journal of Gastroenterology. ,vol. 91, pp. 49- 53 ,(1996)
Wei-Jei Lee, I-Rue Lai, Hshu-Hshing Lin, Ming-Te Huang, Comparison of serum CA72-4, CEA, TPA, CA19-9 and CA125 levels in gastric cancer patients and correlation with recurrence. Hepato-gastroenterology. ,vol. 49, pp. 1157- 1160 ,(2002)
N�v??t Duraker, Al?? Nac?? �el??k, The prognostic significance of preoperative serum CA 19-9 in patients with resectable gastric carcinoma: comparison with CEA. Journal of Surgical Oncology. ,vol. 76, pp. 266- 271 ,(2001) , 10.1002/JSO.1044
Jae-Cheol Jo, Min-Hee Ryu, Dong-Hoe Koo, Baek-Yeol Ryoo, Hwa Jung Kim, Tae Won Kim, Kee Don Choi, Gin Hyug Lee, Hwoon-Yong Jung, Jeong Hwan Yook, Sung Tae Oh, Byung Sik Kim, Jin-Ho Kim, Yoon-Koo Kang, Serum CA 19-9 as a prognostic factor in patients with metastatic gastric cancer. Asia-pacific Journal of Clinical Oncology. ,vol. 9, pp. 324- 330 ,(2013) , 10.1111/AJCO.12019
E.L. Berg, M.K. Robinson, O. Mansson, E.C. Butcher, J.L. Magnani, A carbohydrate domain common to both sialyl Le(a) and sialyl Le(X) is recognized by the endothelial cell leukocyte adhesion molecule ELAM-1. Journal of Biological Chemistry. ,vol. 266, pp. 14869- 14872 ,(1991) , 10.1016/S0021-9258(18)98555-8
Todd M. Bauer, Bassel F. El-Rayes, Xiaobai Li, Nazik Hammad, Philip A. Philip, Anthony F. Shields, Mark M. Zalupski, Tanios Bekaii-Saab, Carbohydrate antigen 19-9 is a prognostic and predictive biomarker in patients with advanced pancreatic cancer who receive gemcitabine-containing chemotherapy: A pooled analysis of 6 prospective trials Cancer. ,vol. 119, pp. 285- 292 ,(2013) , 10.1002/CNCR.27734
A Ra Choi, Jun Chul Park, Jie-Hyun Kim, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee, Jae Bock Chung, High level of preoperative carbohydrate antigen 19-9 is a poor survival predictor in gastric cancer World Journal of Gastroenterology. ,vol. 19, pp. 5302- 5308 ,(2013) , 10.3748/WJG.V19.I32.5302
J L Magnani, B Nilsson, M Brockhaus, D Zopf, Z Steplewski, H Koprowski, V Ginsburg, A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II. Journal of Biological Chemistry. ,vol. 257, pp. 14365- 14369 ,(1982) , 10.1016/S0021-9258(19)45389-1
Ganesa Yogeeswaran, Henry Sebastian, Barry S. Stein, Altered cell surface organization of gangliosides and sialylglycoproteins of mouse metastatic melanoma variant lines selected in vivo for enhanced lung implantation. Cancer Research. ,vol. 38, pp. 1336- 1344 ,(1978)
Hiroshi Yajima, Noburo Omura, Kazuhiko Yoshida, Norio Mitsumori, Katsuhiko Yanaga, Kazuo Matai, Clinicopathological features of CA19-9-producing gastric cancer. Hepato-gastroenterology. ,vol. 61, pp. 221- 225 ,(2014)