Coronary heart disease. Differential hemodynamic, metabolic, and electrocardiographic effects in subjects with and without angina pectoris during atrial pacing.

摘要: Right atrial pacing was performed in 41 subjects with coronary heart disease. Twenty developed angina pectoris during pacing, while 21 did not. The extent of artery disease, as judged by selective cinearteriography, similar the two groups. Both had significant increases rate and pressure-time per minute, but there no difference either these parameters between Among hemodynamic measured, only statistically change cardiac index which fell slightly significantly group. There were differences myocardial oxygen extraction within each group or In group, however, 14 20 exhibited abnormal lactate metabolism pacing. mean highly (P < 0.01). nonangina eight 0.05). correlation electrocardiographic evidence ischemia Sublingual nitroglycerin, given to five continued, resulted prompt relief symptoms, ST-segment depression unaffected after 10 min. By contrast, when anginal symptoms relieved cessation symptomatic improvement accompanied marked Although appears be related subnormal left ventricular function metabolism, is individual variation.