Fenofibrate and renal disease: clinical effects in diabetes

摘要: Fenofibrate is known to increase serum creatinine, but this effect fully reversible, even after long-term treatment. The mechanism underlying poorly understood, fenofibrate not thought impair true glomerular function, as measured by inulin clearance, the gold standard measure of renal function. This iatrogenic creatinine rise does risk adverse outcomes or cardiovascular events. In two large randomized controlled trials patients with Type 2 diabetes, was shown be able reduce albuminuria and slow rate calculated filtration (GFR) loss. beneficial on estimated GFR only unmasked when artificial reduction in removed drug cessation. Interestingly, one trials, greatest fenofibrate-associated appeared derive benefit.