DIRECT GONAD-PITUITARY FEEDBACK: AN ANALYSIS OF EFFECTS OF INTRACRANIAL ESTROGENIC DEPOTS ON GONADOTROPHIN SECRETION.

摘要: In spayed rats, intrapituitary ovarian grafts or estrogenic depots caused castration cells to regress in localized regions. The volume of tissue affected was proportional the estrogen concentration depot. Intrahypothalamic pellets tended reduce size, but not population density, cells, only at higher doses. These slight effects were localized, however. findings suggest that direct hormone may fail influence enough pituitary permit change be detected periphery. possibility a can act directly casts doubt upon interpretation intrahypothalamic reveal an indirect feedback pathway—via neural “receptors.” administration merely most efficient method distributing compound entire adenohypophysis. pertinence this “implantation paradox” is discussed relation large body work aime...