Biomolecular Networks: Methods and Applications in Systems Biology

摘要: PREFACE. ACKNOWLEDGMENTS. LIST OF ILLUSTRATIONS. ACRONYMS. 1 Introduction. 1.1 Basic Concepts in Molecular Biology. 1.2 Biomolecular Networks Cells. 1.3 Network Systems 1.4 About This Book. I GENE NETWORKS. 2 Transcription Regulation: and Models. 2.1 Regulation Gene Expression. 2.2 Regulation. 2.3 Nonlinear Models Based on Biochemical Reactions. 2.4 Integrated for Regulatory Networks. 2.5 Summary. 3 Reconstruction of 3.1 Mathematical Network. 3.2 Reconstructing 3.3 Inferring from Multiple Datasets. 3.4 Network-Based Drug Target Identification. 3.5 4 Inference Transcriptional 4.1 Predicting TF Binding Sites Promoters. 4.2 Interactions. 4.3 Identifying Combinatorial Regulations TFs. 4.4 Cooperative 4.5 Prediction Factor Activity. 4.6 II PROTEIN INTERACTION 5 Protein-Protein 5.1 Experimental 5.2 5.3 Protein Interaction Multidomain Pairs. 5.4 Domain Methods. 5.5 6 Topological Structure 6.1 Statistical Properties 6.2 Evolution 6.3 Hubs, Motifs, Modularity 6.4 Explorative Roles Hubs Motifs. 6.5 Evaluation 6.6 7 Alignment 7.1 Species. 7.2 Pairwise 7.3 by Programming. 7.4 7.5 Subnetwork Pathway Querying. 7.6 8 Function. 8.1 Function Annotation. 8.2 Functional Module Detection. 8.3 Linkage 8.4 High-Throughput Data. 8.5 Annotation Methods Domains. 8.6 III METABOLIC NETWORKS AND SIGNALING 9 Metabolic Networks: Analysis, Reconstruction, Application. 9.1 Cellular Metabolism Pathways. 9.2 Analysis Modeling. 9.3 9.4 Detection 9.5 10 Signaling Modeling Inference. 10.1 Signal Transduction Systems. 10.2 10.3 10.4 Linear 10.5 Evidence. 10.6 11 Other Topics New Trends. 11.1 Structural Analysis. 11.2 Integration 11.3 Posttranscriptional Noncoding RNAs. 11.4 Interactions Human Diseases. 11.5 REFERENCES. INDEX.