Dual-targeted photothermal agents for enhanced cancer therapy

摘要: Photothermal therapy, in which light is converted into heat and triggers local hyperthermia to ablate tumors, presents an inherently specific noninvasive treatment for tumor tissues. In this area, the development of efficient photothermal agents (PTAs) has always been a central topic. Although many efforts have made on investigation novel molecular architectures materials over past decades, PTAs can cause severe damage normal tissues because poor aggregate ability high irradiation density. Recently, dual-targeted (DTPTAs) provide attractive strategy overcome these problems enhance cancer therapy. DTPTAs are functionalized with two classes targeting units, including environment sites, sites organelle sites. perspective, typical targeted ligands representative examples therapeutic properties systematically summarized recent advances using therapy highlighted.