Pancreatic carcinoids (serotonin-producing pancreatic neuroendocrine neoplasms): Report of 5 cases and review of the literature.

摘要: Introduction Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare tumors representing 1% to 2% of all pancreatic neoplasms. These can secrete a variety biologically active substances giving rise distinct clinical symptoms or be clinically nonfunctioning. Apart from insulinomas and gastrinomas, which constitute the majority functioning pNENs, some may serotonin presenting with features carcinoid syndrome. so-called carcinoids considered associated increased urinary levels 5-hydroxyindoleacetic acid (5-HIAA). It has recently been suggested that prevalence such might underestimated. Cases We present series 5 patients our database 138 pNENs (5/138, 3.62%), harboring serotonin-producing describe their distinctive clinical, biochemical, histopathological features, response treatment along review relevant available literature. Conclusion Such rare, although this an underestimate as systematic screening for presence in tissue elevated 5-HIAA apparently nonfunctioning is not currently recommended. In order reach consensus, data large prospective studies needed evaluate impact type survival outcome, since have worse prognosis.