Catechol-modified poly(oxazoline)s with tunable degradability facilitate cell invasion and lateral cartilage integration

摘要: Abstract Tissue adhesives play an important role in clinical applications and may aid the treatment of cartilage defects for improved integration. However, many fail to satisfy demand adequate adhesive strength on wet tissue surfaces facilitate sufficient cell migration extracellular matrix (ECM) deposition at defect site. Utilizing poly(2-alkyl-2-oxazoline) (POx)-based polymers equipped with mussel-inspired adhesion moieties combining them natural wound sealant fibrinogen, we fabricated biosynthethic hydrogel tunable mechanical properties bonding strength. Degradation hydrogels could be adjusted by ratio amide ester linkages catecholic functional group POx side chain. In vitro disc/ring model lateral integration, a benefit long-term integration was observed enhanced degradation without expense Incorporation degradable polymer facilitated invasion strong cartilaginous ECM Overall, results suggest that presented injectable hydrogel, due its easy tunability, holds great potential other medical applications.