Salicylate •Phenanthroline copper (II) complex induces apoptosis in triple-negative breast cancer cells

摘要: // Limei Fan 1, 2, * , Muyou Tian 3, Yunyi Liu Ying Deng 2 Zhengkai Liao 4 Jinhua Xu 1 School of Medicine, Jianghan University, Wuhan, Hubei 430056, China Key Laboratory Optoelectronic Chemical Materials and Devices, Ministry Education, 3 Department Radiation Medical Oncology, Zhongnan Hospital, Wuhan 430071, Tumor Biological Behavior, These authors contributed equally to this work Correspondence to: Liu, email: liuyy1987@jhun.edu.cn Liao, zliao@whu.edu.cn Xu, xu5520@gmail.com Keywords: TNBC, Cu(sal)(phen), cell growth, apoptosis, anti-apoptotic protein Received: December 20, 2016      Accepted: March 03, 2017      Published: 13, 2017 ABSTRACT In study, we investigated anti-tumor activity associated molecular mechanism action Salicylate ●Phenanthroline Copper (II) Complex in triple-negative breast cancer. inhibited the growth four cancer lines (MCF-7, T47D, MDA-MB-231 BT-20) induced apoptosis a concentration-dependent manner. The effect was more profound BT-20 lines. Western blot showed that expression apoptosis-related Bcl-2, Bcl-xl survivin significantly reduced after treatment with Complex. vivo administration attenuated tumor xenografts, levels Bcl-xL were as measured by immunohistochemical staining. data suggest is promising novel therapeutic drug for warrants further study.