Uniformity and physical states of troglitazone in solid dispersions determined by electron probe microanalysis and microthermal analysis.
作者： Susumu Hasegawa , Takeshi Hamaura , Naho Furuyama , Samu Horikawa , Akira Kusai
DOI: 10.1016/J.IJPHARM.2004.04.024
关键词:
摘要: Solid dispersions of troglitazone with PVP K30 in a weight ratio 1:2 were prepared by the closed melting method. that exhibit different degrees crystallinity (0 and 36%) changing charged amount water, which functions as plasticizer for K30. Electron probe microanalysis (EPMA) microthermal analysis (μTA) solid performed to investigate uniformity physical state dispersions. The EPMA study confirmed was dispersed homogeneously sample whose apparent 0%. However, 36% heterogeneous. μTA showed present two states, crystal amorphous. would be useful tools confirm respectively,
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