Sepsis outcomes in patients receiving statins prior to hospitalization for sepsis: comparison of in-hospital mortality rates between patients who received atorvastatin and those who received simvastatin

摘要: The purpose of this study is to compare the in-hospital mortality rates between septic patients receiving statins and those that did not prior developing sepsis. We compared subgroups atorvastatin simvastatin because these two drugs differ in their pharmacologic properties. This was a retrospective analysis selected from an institutional data base hospitalized with were drawn 1,961 sepsis included who met selection criteria studied for HMG-CoA reductase inhibitor (statin) use both during hospitalization. compared. In-hospital patient also A multivariable conducted as outcome variable multiple risk factors include use. rate 359 hospitalization significantly different than 1,302 receive pre-hospital (26.5% versus 30.4%, p > 0.05). 92 had received less 253 (18.5% 30.0%, p = 0.032). independently associated lower (p = 0.021, OR = 0.455). Patients continued hospital very low never (15.7% 30.8%, p = 0.007). Pre-hospital improved when other factors. effect may be individual statins.