LncRNA-AP001631.9 promotes cell migration in gastric cancer.
作者： Yandong Li , Xiaojuan Ye , Hui Cai , Yong Gao , Bin He
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摘要: Recently, an increasing number of reports have revealed that long non-coding RNAs (LncRNAs) play important roles in a variety aspects cell activity, and their aberrant expression is closely associated with multigenetic diseases, including carcinoma. In the present study, through microarray analysis, we screened out new LncRNA (LncRNA-AP001631.9), which was regulated by FOXM1, well-known carcinogenetic factor aimed to reveal functional this novel gastric cancer development. The data from qRT-PCR confirmed level LncRNA-AP001631.9 positively correlated FOXM1. transwell wound healing assays indicated required for migration cells. downregulation small interference RNA suppressed migratory ability MGC803 AGS cells, while overexpression promoted movement BGC823 SGC7901 Furthermore, tail vein injection administered, obtained results suggested contributed distant metastasis Moreover, also collected 36 paired samples tissues explore levels LncRNA-AP001631.9. frequently increased tissues. Taken together, our findings established plays critical progression can serve as potential target treatment cancer.
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