Dynamin-Like Protein 1 Reduction Underlies Mitochondrial Morphology and Distribution Abnormalities in Fibroblasts from Sporadic Alzheimer’s Disease Patients

作者: Xinglong Wang , Bo Su , Hisashi Fujioka , Xiongwei Zhu

DOI: 10.2353/AJPATH.2008.071208

关键词:

摘要: Mitochondrial function relies heavily on its morphology and distribution, alterations of which have been increasingly implicated in neurodegenerative diseases, such as Alzheimer's …

参考文章(57)
Russell H. Swerdlow, Stephen J. Kish, Mitochondria in Alzheimer's disease International Review of Neurobiology. ,vol. 53, pp. 341- 385 ,(2002) , 10.1016/S0074-7742(02)53013-0
Hani Atamna, Jiankang Liu, Bruce N. Ames, Heme Deficiency Selectively Interrupts Assembly of Mitochondrial Complex IV in Human Fibroblasts RELEVANCE TO AGING Journal of Biological Chemistry. ,vol. 276, pp. 48410- 48416 ,(2001) , 10.1074/JBC.M108362200
Jason P. Sheehan, Russel H. Swerdlow, Scott W. Miller, Robert E. Davis, Jan K. Parks, W. Davis Parker, Jeremy B. Tuttle, Calcium Homeostasis and Reactive Oxygen Species Production in Cells Transformed by Mitochondria from Individuals with Sporadic Alzheimer’s Disease The Journal of Neuroscience. ,vol. 17, pp. 4612- 4622 ,(1997) , 10.1523/JNEUROSCI.17-12-04612.1997
Akihiko Nunomura, George Perry, Gjumrakch Aliev, Keisuke Hirai, Atsushi Takeda, Elizabeth K. Balraj, Paul K. Jones, Hossein Ghanbari, Takafumi Wataya, Shun Shimohama, Shigeru Chiba, Craig S. Atwood, Robert B. Petersen, Mark A. Smith, Oxidative damage is the earliest event in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. ,vol. 60, pp. 759- 767 ,(2001) , 10.1093/JNEN/60.8.759
Christiane Alexander, Marcela Votruba, Ulrike E.A. Pesch, Dawn L. Thiselton, Simone Mayer, Anthony Moore, Miguel Rodriguez, Ulrich Kellner, Beate Leo-Kottler, Georg Auburger, Shomi S. Bhattacharya, Bernd Wissinger, OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28. Nature Genetics. ,vol. 26, pp. 211- 215 ,(2000) , 10.1038/79944
Yang-ja Lee, Seon-Yong Jeong, Mariusz Karbowski, Carolyn L. Smith, Richard J. Youle, Roles of the Mammalian Mitochondrial Fission and Fusion Mediators Fis1, Drp1, and Opa1 in Apoptosis Molecular Biology of the Cell. ,vol. 15, pp. 5001- 5011 ,(2004) , 10.1091/MBC.E04-04-0294
Patrik Verstreken, Cindy V. Ly, Koen J.T. Venken, Tong-Wey Koh, Yi Zhou, Hugo J. Bellen, Synaptic Mitochondria Are Critical for Mobilization of Reserve Pool Vesicles at Drosophila Neuromuscular Junctions Neuron. ,vol. 47, pp. 365- 378 ,(2005) , 10.1016/J.NEURON.2005.06.018
Patricia A. Trimmer, Russell H. Swerdlow, Janice K. Parks, Paula Keeney, James P. Bennett, Scott W. Miller, Robert E. Davis, W.Davis Parker, Abnormal Mitochondrial Morphology in Sporadic Parkinson's and Alzheimer's Disease Cybrid Cell Lines Experimental Neurology. ,vol. 162, pp. 37- 50 ,(2000) , 10.1006/EXNR.2000.7333