DNA vaccine compositions and methods of use

作者: Opendra Narayan , Zhenqian Liu

DOI:

关键词:

摘要: The present invention is directed to a DNA vaccine for immunization against HIV. comprises molecule that has sequence encoding plurality of viral proteins capable stimulating an immune response rendered safe use as by the disruption genes reverse transcriptase, integrase, and Vif. further at least partial deletion 3' LTR.

参考文章(14)
Edward B. Stephens, Sampa Mukherjee, Manisha Sahni, Wu Zhuge, Ravi Raghavan, Dinesh K. Singh, Kevin Leung, Bruce Atkinson, Zhuang Li, Sanjay V. Joag, Zhen Qian Liu, Opendra Narayan, A Cell-Free Stock of Simian–Human Immunodeficiency Virus That Causes AIDS in Pig-Tailed Macaques Has a Limited Number of Amino Acid Substitutions in Both SIVmacand HIV-1 Regions of the Genome and Has Altered Cytotropism Virology. ,vol. 231, pp. 313- 321 ,(1997) , 10.1006/VIRO.1997.8534
Zhen Qian Liu, Sampa Muhkerjee, Manisha Sahni, Coleen McCormick-Davis, Kevin Leung, Zhaung Li, Vincent H. Gattone, Chinqiao Tian, Robert W. Doms, Trevor L. Hoffman, Ravi Raghavan, Opendra Narayan, Edward B. Stephens, Derivation and Biological Characterization of a Molecular Clone of SHIVKU-2 That Causes AIDS, Neurological Disease, and Renal Disease in Rhesus Macaques Virology. ,vol. 260, pp. 295- 307 ,(1999) , 10.1006/VIRO.1999.9812
James M. Smith, Nancy J. Leung, José V. Torres, Preparation and Induction of Immune Responses by a DNA AIDS Vaccine Viral Immunology. ,vol. 13, pp. 343- 351 ,(2000) , 10.1089/08828240050144662
S. Sopper, E. Koutsilieri, C. Scheller, S. Czub, P. Riederer, V. ter Meulen, Macaque animal model for HIV-induced neurological disease. Journal of Neural Transmission. ,vol. 109, pp. 747- 766 ,(2002) , 10.1007/S007020200062
E. Kotsopoulou, V. N. Kim, A. J. Kingsman, S. M. Kingsman, K. A. Mitrophanous, A Rev-Independent Human Immunodeficiency Virus Type 1 (HIV-1)-Based Vector That Exploits a Codon-Optimized HIV-1 gag-pol Gene Journal of Virology. ,vol. 74, pp. 4839- 4852 ,(2000) , 10.1128/JVI.74.10.4839-4852.2000
Anil Kumar, Jeffrey D. Lifson, Zhuang Li, Fenglan Jia, Sampa Mukherjee, Istvan Adany, Zhenqian Liu, Mike Piatak, Darlene Sheffer, Harold M. McClure, Opendra Narayan, Sequential Immunization of Macaques with Two Differentially Attenuated Vaccines Induced Long-Term Virus-Specific Immune Responses and Conferred Protection against AIDS Caused by Heterologous Simian Human Immunodeficiency Virus (SHIV89.6P) Virology. ,vol. 279, pp. 241- 256 ,(2001) , 10.1006/VIRO.2000.0695
Dan H Barouch, Sampa Santra, Jorn E Schmitz, Marcelo J Kuroda, Tong-Ming Fu, Wendeline Wagner, Miroslawa Bilska, Abie Craiu, Xin Xiao Zheng, Georgia R Krivulka, Kristin Beaudry, Michelle A Lifton, Christine E Nickerson, Wendy L Trigona, Kara Punt, Dan C Freed, Liming Guan, Sheri Dubey, Danilo Casimiro, Adam Simon, Mary-Ellen Davies, Michael Chastain, Terry B Strom, Rebecca S Gelman, David C Montefiori, Mark G Lewis, Emilio A Emini, John W Shiver, Norman L Letvin, Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination Science. ,vol. 290, pp. 486- 492 ,(2000) , 10.1126/SCIENCE.290.5491.486
Sanjay V. Joag, Zhen Qian Liu, Edward B. Stephens, Marilyn S. Smith, Anil Kumar, Zhuang Li, Chunyang Wang, Darlene Sheffer, Fenglan Jia, Larry Foresman, Istvan Adany, Jeff Lifson, Harold M. McClure, Opendra Narayan, Oral Immunization of Macaques with Attenuated Vaccine Virus Induces Protection against Vaginally Transmitted AIDS Journal of Virology. ,vol. 72, pp. 9069- 9078 ,(1998) , 10.1128/JVI.72.11.9069-9078.1998