Tris (2-butoxyethyl) phosphate affects motor behavior and axonal growth in zebrafish (Danio rerio) larvae.
作者： Fan Jiang , Jue Liu , Xinyue Zeng , Liqin Yu , Chunsheng Liu
DOI: 10.1016/J.AQUATOX.2018.03.012
关键词:
摘要: Abstract Tris (2-butoxyethyl) phosphate (TBOEP) is an environmental contaminant that poses serious risks to aquatic organisms and their associated ecosystem. Recently, the reproductive developmental toxicology of TBOEP has been reported. However, fewer studies have assessed neurotoxic effects in zebrafish (Danio rerio) larvae. In this study, embryos were subjected waterborne exposure at 0, 50, 500, 1500 2500 μg/L from 2 144-h post-fertilization (hpf). Behavioral measurements showed reduced embryonic spontaneous movement decreased swimming speed larvae response dark stimulation. accordance with these motor effects, treatment neuron-specific GFP expression transgenic Tg (HuC-GFP) inhibited growth secondary motoneurons, as well marker genes related central nervous system development treated group. Furthermore, increased concentrations reactive oxygen species (ROS) malondialdehyde (MDA), reduction SOD activity detected The present results alteration neuron oxidative stress could together lead behavior alterations induced by TBOEP.
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