Environmental enrichment exerts sex-specific effects on emotionality in C57BL/6J mice

摘要: Environmental enrichment (EE) has been shown to exert various behavioral and mood effects in rodents including emotionality, which a high propensity be influenced by sex. However, there are only few comparative studies evaluating the effect of EE their results both inconsistent inconclusive. In present study, male female C57BL/6J adolescent mice were housed either physical or standard conditions for four weeks with analysis affective behaviors open field, elevated T-maze forced swim tests. Hippocampal gene expression was characterized an additional group mice. field test, exploration similarly inhibited Both sex housing condition time spent center arena. T-maze, anxiety-like behavior increased decreased following EE. We observed trend EE-induced inhibition glucocorticoid receptor (GR) mRNA but not contrast, mineralocorticoid (MR) unaffected 10 days lower compared Our data suggest that balance between hippocampal GR MR may contribute sex-specific on emotionality-related behavior.