SOME DIFFERENCES IN THE ACTION OF PENICILLIN, BACITRACIN, AND VANCOMYCIN ON BACILLUS MEGATERIUM

摘要: Hancock, R. (Harvard Medical School, Boston, Mass.), and P. C. Fitz-James. Some differences in the action of penicillin, bacitracin, vancomycin on Bacillus megaterium. J. Bacteriol. 87:1044-1050. 1964.-Penicillin cycloserine do not inhibit growth protoplasts megaterium, indicating that inhibition cell-wall synthesis is only significant process by which they bacteria. In contrast, bacitracin bacteria at similar concentrations, have important sites other than their known synthesis. At concentrations mucopeptide synthesis, each cause an increased rate efflux K ions from growing This effect penicillin prevented chloramphenicol or hypertonic sucrose, whereas effects are unchanged under these conditions. It concluded direct cytoplasmic membrane, it proposed could be a consequence effects. Bacitracin compete with for binding to cells B. further indication different primary site action.