Isolation of a new cytotoxic polyhydroxysterol from the South China Sea soft coral Sinularia sp.
作者： Huan Sun , Fen Liu , Mei-Ran Feng , Qi Peng , Xiao-Jian Liao
DOI: 10.1080/14786419.2016.1166495
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摘要: AbstractA new polyhydroxysterol, (22E)-24-methylenecholestane-22-ene-3β,5α,6β-triol (1), together with four known analogues (2–5) were isolated from the South China Sea soft coral Sinularia sp. Their structures elucidated by spectroscopic analyses and comparison previously reported data. All these compounds exhibited cytotoxic effect against both HepG2 HeLa cell lines IC50 values ranging 8.36 to 37.30 μM. Preliminary structure–activity relationship study identified that presence of double bonds in side chains polyhydroxysterols significantly reduced biological obtained.
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