Homozygous thermolabile methylenetetrahydrofolate reductase in schizophrenia-like psychosis

摘要: The gene for methylenetetrahydrofolate reductase (MTHFR) has shown polymorphism in the general human population. In its homozygous form, a C677T mutation occurs more than 5% of grown-up population and produces thermolabile variant which reduces overall enzyme activity to less 30% normal. We investigated patients with schizophrenia-like psychosis. If hyperhomocysteinemic, their DNA-genotype was determined. Seven 11 patients, six males one female, were MTHFR. One male patient heterozygous all three normal homozygotes females. who mutation, homocysteine concentrations did not respond vitamin B12 but normalized by folate supplementation. homozygotes, however, reduced alone. Our results suggest that homozygosity MTHFR is risk factor Possibly, this may be