Psychosis after resection of ganglioglioma or DNET : Evidence for an association

摘要: Summary: Purpose: David Taylor and Murray Falconer suggested that some patients may develop a psychotic illness after resection of ganglioglioma led to intractable seizures. They implied the mechanism this association remained unclear. This concept is currently not universally accepted (M. Trimble, personal communication). Methods: We studied six children or young adults from four centers who developed psychosis dysembryoplastic neuroepithelioma (DNET). Results: All were operated on because epilepsy. The lesions involved mainly temporal lobe. Patients had good outcomes for seizure control. In none was potentially psychogenic medication used nor symptoms postictal in nature. schizophreniform with paranoid features prominent depressive symptoms. Although behavioral abnormalities described preoperatively, been before operation. type reaction encountered comparable period other types lesions. complication rare; it occurred only one 39 such lesion resected. Conclusions: Psychotic rarely occur DNET treatment does seem removal Because seizures, be related “forced normalization.” original observations are confirmed by study; reasons selective occurrence, however, remain speculative.