Resistance to Macrolides and Related Antibiotics in Streptococcus pneumoniae

摘要: Resistance to erythromycin in Streptococcus pneumoniae was first detected 1967 the United States and subsequently worldwide (11, 20). The corresponding mechanism rapidly identified as ribosomal methylation, which had been primarily reported being responsible for resistance staphylococci (44). Further spread of then noted a few countries, such France, where hospitals observed sharp increase proportion resistant pneumococci, reached approximately 20% 1984 (16). This trend several years before emergence penicillin pneumococci France. Recently, an increasing number countries have changes evolution macrolide resistance. In some them, States, increased incidence has correlated with new resistance—efflux (39). review is devoted mechanisms macrolides related antibiotics pneumococci.