Reserpine: interactions with batrachotoxin and brevetoxin sites on voltage-dependent sodium channels.
作者： Andrew Flowers , Kenolisa Onwueme , Cyrus R. Creveling , John W. Daly
关键词:
摘要: Reserpine inhibited batrachotoxin-elicited sodium influx in guinea pig brain synaptoneurosomes with an IC50 of about 1 μM. In the presence brevetoxin increased to 80 binding batrachotoxinin-A [3H]benzoate ([3H]BTX-B) a complex manner causing partial inhibition from 0.001 0.08 μM, then rebound stimulation 0.1 0.8 followed by complete The was prevented brevetoxin; reserpine smoothly at μM slightly reduced off-rate [3H]BTX-B measured veratridine, while concentration 50 it enhanced off-rate, presumably allosteric mechanism. 0.3–10 elicited [3H]brevetoxin-3. local anesthetic dibucaine had effects similar reserpine: It partially [3H]brevetoxin. potency as inhibitor 2 results suggest that binds both site cause batrachotoxin-binding and action, but also another causing, like brevetoxin, enhancement action. Local anesthetics may bind site.
springer.com
sci-hub.se 参考文章(21)
Cyrus R. Creveling, John W. Daly, Batrachotoxinin A [3H]Benzoate Binding to Sodium Channels Methods in Neurosciences. ,vol. 8, pp. 25- 37 ,(1992) , 10.1016/B978-0-12-185266-5.50008-7
W A Catterall, C S Morrow, J W Daly, G B Brown, Binding of batrachotoxinin A 20-alpha-benzoate to a receptor site associated with sodium channels in synaptic nerve ending particles. Journal of Biological Chemistry. ,vol. 256, pp. 8922- 8927 ,(1981) , 10.1016/S0021-9258(19)52487-5
EB Hollingsworth, ET McNeal, JL Burton, RJ Williams, JW Daly, CR Creveling, Biochemical characterization of a filtered synaptoneurosome preparation from guinea pig cerebral cortex: cyclic adenosine 3':5'-monophosphate- generating systems, receptors, and enzymes The Journal of Neuroscience. ,vol. 5, pp. 2240- 2253 ,(1985) , 10.1523/JNEUROSCI.05-08-02240.1985
W. A. Catterall, Cellular and molecular biology of voltage-gated sodium channels. Physiological Reviews. ,vol. 72, ,(1992) , 10.1152/PHYSREV.1992.72.SUPPL_4.S15
H J Duff, R S Sheldon, R J Hill, E Thakore, Class I antiarrhythmic drugs: allosteric inhibitors of [3H] batrachotoxinin binding to rat cardiac sodium channels. Journal of Pharmacology and Experimental Therapeutics. ,vol. 268, pp. 187- 194 ,(1994)
E T McNeal, J W Daly, C R Creveling, G B Brown, Batrachotoxin-induced depolarization and [3H]batrachotoxinin-a 20 alpha-benzoate binding in a vesicular preparation from guinea pig cerebral cortex. Molecular Pharmacology. ,vol. 23, pp. 350- 358 ,(1983)
Elizabeth T. McNeal, Gail A. Lewandowski, John W. Daly, C. R. Creveling, [3H]Batrachotoxinin A 20.alpha.-benzoate binding to voltage-sensitive sodium channels: a rapid and quanitative assay for local anesthetic activity in a variety of drugs Journal of Medicinal Chemistry. ,vol. 28, pp. 381- 388 ,(1985) , 10.1021/JM00381A019
Sandrine Cestèle, Fran¸ois Sampieri, Hervé Rochat, Dalia Gordon, Tetrodotoxin Reverses Brevetoxin Allosteric Inhibition of Scorpion α-Toxin Binding on Rat Brain Sodium Channels Journal of Biological Chemistry. ,vol. 271, pp. 18329- 18332 ,(1996) , 10.1074/JBC.271.31.18329
Ildiko Zimanyi, Abel Lajtha, E.Sylvester Vizi, Maarten E.A. Reith, Interaction of yohimbine with batrachotoxinin binding to mouse brain sodium channels. Biochemical Pharmacology. ,vol. 37, pp. 641- 645 ,(1988) , 10.1016/0006-2952(88)90137-2
T. Tokuyama, J.W. Daly, Steroidal alkaloids (batrachotoxins and 4β-hydroxybatrachotoxins), “indole alkaloids” (calycanthine and chimonanthine) and a piperidinyldipyridin Tetrahedron. ,vol. 39, pp. 41- 47 ,(1983) , 10.1016/S0040-4020(01)97627-6