摘要: A functional ubiquitin proteasome system is essential for all eukaryotic cells and therefore any alteration to its components has potential pathological consequences. Though the exact underlying mechanism unclear, an age-related decrease in activity weakens cellular capacity remove oxidatively modified proteins favours development of neurodegenerative cardiac diseases. Up-regulation characteristic muscle wasting conditions including sepsis, cachexia uraemia, but may not be rate limiting. Meanwhile, enhanced presence immunoproteasomes aging brain tissue could reflect a persistent inflammatory defence anti-stress mechanism, whereas cancer cells, their down-regulation reflects means by which escape immune surveillance. Hence, induction apoptosis synthetic inhibitors treatment strategy cancer, other diseases such as neurodegeneration, use proteasome-activating or -modulating compounds more effective. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com).
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