Dedifferentiation in low-grade mucoepidermoid carcinoma of the parotid gland

摘要: Mucoepidermoid carcinoma (MEC), a common malignant salivary gland neoplasm, is generally divided into low-, intermediate-, and high-grade types according to the histologic features. To our knowledge, present report describes first case of dedifferentiation occurring in low-grade MEC. A 55-year-old man presented with biphasic neoplasm right parotid composed MEC dedifferentiated anaplastic undifferentiated carcinoma. Immunohistochemically, carcinoembryonic antigen expression was restricted portion. The Ki-67-labeling index higher component than component. On image cytometric analysis, diploid, whereas aneuploid. Although patient alive 10 years after initial diagnosis, tumor has recurred twice, at 3 months 7 resection. It important recognize that can occur MEC, similar other carcinomas.