The Emergence of Human Coronavirus EMC: How Scared Should We Be?

摘要: A novel betacoronavirus, human coronavirus (HCoV-EMC), has recently been detected in humans with severe respiratory disease. Further characterization of HCoV-EMC suggests that this virus is different from acute syndrome (SARS-CoV) because it able to replicate multiple mammalian cell lines and does not use angiotensin-converting enzyme 2 as a receptor achieve infection. Additional research urgently needed better understand the pathogenicity tissue tropism humans. In their recent study published mBio, Kindler et al. shed some light on these important topics (E. Kindler, H. R. Jonsdottir, M. Muth, O. J. Hamming, Hartmann, Rodriguez, Geffers, A. Fouchier, C. Drosten, Muller, Dijkman, V. Thiel, mBio 4[1]:e00611-12, 2013). These authors report differentiated pseudostratified primary airway epithelial cells, an vitro model high physiological relevance epithelium, characterize cellular HCoV-EMC. More importantly, demonstrate potential type I III interferons (IFNs) control viral