Aberrant proliferation and differentiation of glycogen storage disease type Ib mesenchymal stem cells.
作者： Sang Wan Sim , Tae Sub Park , Sung‐Jo Kim , Byung‐Chul Park , David A. Weinstein
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摘要: Glycogen storage disease type Ib (GSD-Ib) is caused by mutations of the glucose-6-phosphate transporter (G6PT) and characterized disrupted glucose homeostasis, neutropenia, neutrophil dysfunction. To investigate role G6PT in human adipose-derived mesenchymal stem cells (hMSCs), gene was mutated CRISPR/Cas9 technology single cell-derived G6PT-/- hMSCs were established. have significantly increased cell proliferation but impaired adipogenesis osteogenesis. These phenotypes are associated with two mechanisms: i) metabolic reprogramming causing a shift toward glycolysis rather than oxidative phosphorylation ii) cyclooxygenase-2-derived prostaglandin E2 secretion hMSCs. This study demonstrates that essential for differentiation MSCs, providing important insights into GSD-Ib phenotypes.
sci-hub.se 参考文章(26)
Janice Yang Chou, The molecular basis of type 1 glycogen storage diseases. Current Molecular Medicine. ,vol. 1, pp. 25- 44 ,(2001) , 10.2174/1566524013364112
Girish Pattappa, Hannah K. Heywood, Joost D. de Bruijn, David A. Lee, The metabolism of human mesenchymal stem cells during proliferation and differentiation. Journal of Cellular Physiology. ,vol. 226, pp. 2562- 2570 ,(2011) , 10.1002/JCP.22605
Antonio Uccelli, Lorenzo Moretta, Vito Pistoia, Mesenchymal stem cells in health and disease Nature Reviews Immunology. ,vol. 8, pp. 726- 736 ,(2008) , 10.1038/NRI2395
Hyun Sik Jun, David A. Weinstein, Young Mok Lee, Brian C. Mansfield, Janice Y. Chou, Molecular mechanisms of neutrophil dysfunction in glycogen storage disease type Ib. Blood. ,vol. 123, pp. 2843- 2853 ,(2014) , 10.1182/BLOOD-2013-05-502435
Yanmin Zhang, Glenn Marsboom, Peter T. Toth, Jalees Rehman, Mitochondrial Respiration Regulates Adipogenic Differentiation of Human Mesenchymal Stem Cells PLoS ONE. ,vol. 8, pp. e77077- ,(2013) , 10.1371/JOURNAL.PONE.0077077
So Youn Kim, Hyun Sik Jun, Paul A. Mead, Brian C. Mansfield, Janice Y. Chou, Neutrophil stress and apoptosis underlie myeloid dysfunction in glycogen storage disease type Ib. Blood. ,vol. 111, pp. 5704- 5711 ,(2008) , 10.1182/BLOOD-2007-12-129114
Claire Pecqueur, Thi Bui, Chantal Gelly, Julie Hauchard, Céline Barbot, Frederic Bouillaud, Daniel Ricquier, Bruno Miroux, Craig B. Thompson, Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization The FASEB Journal. ,vol. 22, pp. 9- 18 ,(2008) , 10.1096/FJ.07-8945COM
Pauline Esteves, Claire Pecqueur, Céline Ransy, Catherine Esnous, Véronique Lenoir, Frédéric Bouillaud, Anne-Laure Bulteau, Anne Lombès, Carina Prip-Buus, Daniel Ricquier, Marie-Clotilde Alves-Guerra, Mitochondrial Retrograde Signaling Mediated by UCP2 Inhibits Cancer Cell Proliferation and Tumorigenesis Cancer Research. ,vol. 74, pp. 3971- 3982 ,(2014) , 10.1158/0008-5472.CAN-13-3383
Kaan Boztug, Giridharan Appaswamy, Angel Ashikov, Alejandro A. Schäffer, Ulrich Salzer, Jana Diestelhorst, Manuela Germeshausen, Gudrun Brandes, Jacqueline Lee-Gossler, Fatih Noyan, Anna-Katherina Gatzke, Milen Minkov, Johann Greil, Christian Kratz, Theoni Petropoulou, Isabelle Pellier, Christine Bellanné-Chantelot, Nima Rezaei, Kirsten Mönkemöller, Noha Irani-Hakimeh, Hans Bakker, Rita Gerardy-Schahn, Cornelia Zeidler, Bodo Grimbacher, Karl Welte, Christoph Klein, A Syndrome with Congenital Neutropenia and Mutations in G6PC3 The New England Journal of Medicine. ,vol. 360, pp. 32- 43 ,(2009) , 10.1056/NEJMOA0805051
Ryang Hwa Lee, ByungChul Kim, IkSoo Choi, Hanna Kim, Hee Sun Choi, KeunTak Suh, Yong Chan Bae, Jin Sup Jung, Characterization and Expression Analysis of Mesenchymal Stem Cells from Human Bone Marrow and Adipose Tissue Cellular Physiology and Biochemistry. ,vol. 14, pp. 311- 324 ,(2004) , 10.1159/000080341