Presence of Phosphodiesterase Type 5 in the Spinal Cord and its Involvement in Bladder Outflow Obstruction Related Bladder Overactivity
作者： Claudius Füllhase , Martin Hennenberg , Armin Giese , Michael Schmidt , Frank Strittmatter
DOI: 10.1016/J.JURO.2013.03.112
关键词:
摘要: Purpose: Phosphodiesterase type 5 inhibitors were recently introduced as a new treatment option for men with lower urinary tract symptoms. Safety and clinical effectiveness are well documented but the mode of action is still unclear. We determined compared expression phosphodiesterase in spinal cord normal (sham operated) rats partial urethral obstruction induced bladder overactivity. also assessed urodynamic effects intravenously intrathecally administered sildenafil to determine whether exert on sacral spinal cord.Materials Methods: A total 65 male Sprague-Dawley® used molecular/morphological functional experiments. Bladder overactivity was via surgical 39 rats. Spinal by histology polymerase chain reaction. The or intrath...
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