Rapid Multistep Synthesis of a Bioactive Peptidomimetic Oligomer for the Undergraduate Laboratory.

摘要: Peptidomimetic compounds are increasingly important in drug-discovery applications. We introduce the synthesis of an N-substituted glycine oligomer, a bioactive “peptoid” trimer. The six-step protocol is conducted on solid-phase resin, enabling to be performed by undergraduate organic chemistry students. This lab was successfully completed within one 4-h session second-year procedures relatively inexpensive and versatile, modifications generate variety oligomer sequences from commercially available reagents including bromoacetic acid diverse set primary amines.