Temporal differences in membrane loss lead to distinct reticulocyte features in hereditary spherocytosis and in immune hemolytic anemia.

摘要: Spherocytic red cells with reduced membrane surface area are a feature of hereditary spherocytosis (HS) and some forms autoimmune hemolytic anemia (AIHA). It is generally assumed that loss in spherocytic occurs during their sojourn circulation. The structural basis for HS improper assembly proteins, whereas AIHA it due to partial phagocytosis circulating by macrophages. A hypothesis was formed these different mechanisms should lead temporal differences cell genesis circulation 2 syndromes. proposed could begin at the reticulocyte stage HS, involves only mature cells. validity this established documenting cellular features reticulocytes AIHA. Using novel technique quantitate area, decreased both compared normal documented. In contrast, but not exhibited area. These data imply AIHA, already present stage. findings an early event challenge existing concepts predominantly