VEGF promotes malaria-associated acute lung injury in mice

摘要: The spectrum of the clinical presentation and severity malaria infections is broad, ranging from uncomplicated febrile illness to severe forms disease such as cerebral (CM), acute lung injury (ALI), respiratory distress syndrome (ARDS), pregnancy-associated (PAM) or anemia (SA). Rodent models that mimic human CM, PAM SA syndromes have been established. Here, we show DBA/2 mice infected with P. berghei ANKA constitute a new model for malaria-associated ALI. Up 60% showed dyspnea, airway obstruction hypoxemia died between days 7 12 post-infection. most common pathological findings were pleural effusion, pulmonary hemorrhage edema, consistent increased vessel permeability, while blood-brain barrier was intact. Malaria-associated ALI correlated high levels circulating VEGF, produced de novo in spleen, its blockage led protection this syndrome. In addition, either splenectomization administration anti-inflammatory molecule carbon monoxide significant reduction sera VEGF similarities physiopathological lesions described here ones occurring humans, well demonstration critical host factor onset mice, not only offers important mechanistic insights into processes underlying pathology related but may also pave way interventional studies.