The use of the Calvert formula to determine the optimal carboplatin dosage

摘要: Carboplatin is a chemotherapeutic agent frequently used in the treatment of various malignancies. The myelotoxicity and clinical efficacy carboplatin correlate with clearance drug, which correlated to glomerular filtration rate (GFR). Dosing this based solely upon patients body surface area therefore not accurate enough; GFR, thus differ each patient irrespective area. Consequently, some undergo higher systemic exposure, expressed as under plasma concentration/time curve (AUC), than others when dosages are given on basis A high AUC correlates increased toxicity, increasing risks treatment, but case low therapeutical decreases. This indicates that an individual dosing strategy warranted obtain optimal AUC. In article, development application simple equation, known Calvert formula, discussed. formula can be calculate dose accurately order target by using only GFR. is: (mg)=AUC (mg ml−1 min)×[GFR (ml/min)+25 (ml/min)]. has proven be, both retrospective prospective studies, reliable tool carboplatin. Future studies should determine value creatinine measure for